Top 100 Most Cited

The 100 most-cited papers across the perianal & luminal Crohn's-disease literature, by citation count (NIH Open Citation Collection).

Curated by · Professor of Surgery, Department of Colon & Rectal Surgery, Cleveland Clinic · Corpus last refreshed · Publications

Ranked from the perianal & luminal Crohn's-disease literature.

A research reference for clinicians and trainees: rankings are drawn from the published literature, not treatment advice. Always talk with your own care team about what any study means for you.

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1Infliximab for the treatment of fistulas in patients with Crohn's disease.
Present DH · 1999 · N Engl J Med
2,135
2British Society of Gastroenterology consensus guidelines on the management of inflammatory bowel disease in adults.
Lamb · 2019 · Gut
1,838
3Infliximab maintenance therapy for fistulizing Crohn's disease.
Sands BE · 2004 · N Engl J Med
1,716
43rd European Evidence-based Consensus on the Diagnosis and Management of Crohn's Disease 2016: Part 1: Diagnosis and Medical Management.
Gomollón F · 2017 · J Crohns Colitis
1,567
5Inflammatory bowel disease: clinical aspects and established and evolving therapies
Baumgart · 2007 · Lancet
1,444
6The second European evidence-based Consensus on the diagnosis and management of Crohn's disease: Current management.
2010 · J Crohns Colitis
1,107
7ECCO Guidelines on Therapeutics in Crohn's Disease: Medical Treatment.
Torres J · 2020 · J Crohns Colitis
1,097
8The extra-intestinal complications of Crohn's disease and ulcerative colitis: a study of 700 patients.
Greenstein · 1976 · Medicine (Baltimore)
1,063
9Ileal pouch-anal anastomoses complications and function in 1005 patients
Fazio · 1995 · Ann Surg
959
10Immunoregulatory mechanisms of mesenchymal stem and stromal cells in inflammatory diseases.
Shi Y · 2018 · Nat Rev Nephrol
930
11The second European evidence-based Consensus on the diagnosis and management of Crohn's disease: Definitions and diagnosis.
2010 · J Crohns Colitis
857
12Expanded allogeneic adipose-derived mesenchymal stem cells (Cx601) for complex perianal fistulas in Crohn's disease: a phase 3 randomised, double-blind controlled trial.
Panés J · 2016 · Lancet
821
13Consensus guidelines of ECCO/ESPGHAN on the medical management of pediatric Crohn's disease.
Ruemmele FM · 2014 · J Crohns Colitis
815
14The natural history of fistulizing Crohn's disease in Olmsted County, Minnesota.
Schwartz DA · 2002 · Gastroenterology
801
15Therapeutic manipulation of the enteric microflora in inflammatory bowel diseases: antibiotics, probiotics, and prebiotics
Sartor · 2004 · Gastroenterology
758
16Predictors of Crohn's disease.
Beaugerie L · 2006 · Gastroenterology
714
17Early lesions of recurrent Crohn's disease caused by infusion of intestinal contents in excluded ileum.
D'Haens · 1998 · Gastroenterology
682
18Mesenchymal stem cells: mechanisms of inflammation.
Singer NG · 2011 · Annu Rev Pathol
661
19Incidence and phenotype of inflammatory bowel disease based on results from the Asia-pacific Crohn's and colitis epidemiology study.
Ng SC · 2013 · Gastroenterology
650
20Risk factors associated with progression to intestinal complications of Crohn's disease in a population-based cohort.
Thia KT · 2010 · Gastroenterology
639
21Effect of faecal stream diversion on recurrence of Crohn's disease in the neoterminal ileum.
Rutgeerts · 1991 · Lancet
598
22A phase I clinical trial of the treatment of Crohn's fistula by adipose mesenchymal stem cell transplantation.
García-Olmo D · 2005 · Dis Colon Rectum
587
233rd European Evidence-based Consensus on the Diagnosis and Management of Crohn's Disease 2016: Part 2: Surgical Management and Special Situations.
Gionchetti P · 2017 · J Crohns Colitis
579
24Expanded adipose-derived stem cells for the treatment of complex perianal fistula: a phase II clinical trial.
Garcia-Olmo D · 2009 · Dis Colon Rectum
573
25The Medical Management of Paediatric Crohn's Disease: an ECCO-ESPGHAN Guideline Update.
van Rheenen PF · 2021 · J Crohns Colitis
552
26Risk factors for surgery and postoperative recurrence in Crohn's disease.
Bernell O · 2000 · Ann Surg
517
27Making a definitive diagnosis: successful clinical application of whole exome sequencing in a child with intractable inflammatory bowel disease.
Worthey EA · 2011 · Genet Med
516
28Adipose-derived mesenchymal stem cells alleviate experimental colitis by inhibiting inflammatory and autoimmune responses.
González MA · 2009 · Gastroenterology
503
29Efficacy and safety of tumor necrosis factor antagonists in Crohn's disease: meta-analysis of placebo-controlled trials.
Peyrin-Biroulet L · 2008 · Clin Gastroenterol Hepatol
482
30Infliximab maintenance treatment reduces hospitalizations, surgeries, and procedures in fistulizing Crohn's disease.
Lichtenstein GR · 2005 · Gastroenterology
470
31Biological functions of mesenchymal stem cells and clinical implications.
Naji A · 2019 · Cell Mol Life Sci
443
32National Cooperative Crohn's Disease Study: extraintestinal manifestations and perianal complications.
Rankin GB · 1979 · Gastroenterology
443
33AGA technical review on perianal Crohn's disease.
Sandborn WJ · 2003 · Gastroenterology
441
34Autologous bone marrow-derived mesenchymal stromal cells in the treatment of fistulising Crohn's disease.
Ciccocioppo R · 2011 · Gut
440
35Long-term follow-up of patients with Crohn's disease. Relationship between the clinical pattern and prognosis.
Farmer RG · 1985 · Gastroenterology
428
36ECCO Guidelines on Therapeutics in Crohn's Disease: Surgical Treatment.
Adamina M · 2020 · J Crohns Colitis
426
37European evidence based consensus on the diagnosis and management of Crohn's disease: current management.
2006 · Gut
421
38Antibiotic therapy in inflammatory bowel disease: a systematic review and meta-analysis.
Khan KJ · 2011 · Am J Gastroenterol
399
39Evidence-based clinical practice guidelines for inflammatory bowel disease
Matsuoka · 2018 · J Gastroenterol
398
40Metronidazole therapy for perineal Crohn's disease: a follow-up study.
Brandt LJ · 1982 · Gastroenterology
395
41A meta-analysis of anal cancer incidence by risk group: Toward a unified anal cancer risk scale.
Clifford GM · 2021 · Int J Cancer
393
42Management of Paediatric Ulcerative Colitis, Part 1: Ambulatory Care-An Evidence-based Guideline From European Crohn's and Colitis Organization and European Society of Paediatric Gastroenterology, Hepatology and Nutrition
Turner · 2018 · J Pediatr Gastroenterol Nutr
387
43A comprehensive review and update on Crohn's disease.
Gajendran M · 2018 · Dis Mon
382
44Crohn Disease: Epidemiology, Diagnosis, and Management.
Feuerstein JD · 2017 · Mayo Clin Proc
374
45Antitumor necrosis factor therapy for inflammatory bowel disease: a review of agents, pharmacology, clinical results, and safety.
Sandborn WJ · 1999 · Inflamm Bowel Dis
370
46Occurrence and outcome after primary treatment of anal fistulae in Crohn's disease.
Hellers · 1980 · Gut
364
47The Toronto Consensus Statements for the Management of Inflammatory Bowel Disease in Pregnancy.
Nguyen GC · 2016 · Gastroenterology
360
48Long-term Efficacy and Safety of Stem Cell Therapy (Cx601) for Complex Perianal Fistulas in Patients With Crohn's Disease.
Panés J · 2018 · Gastroenterology
355
49The London Position Statement of the World Congress of Gastroenterology on Biological Therapy for IBD with the European Crohn's and Colitis Organization: when to start, when to stop, which drug to choose, and how to predict response?
D'Haens GR · 2011 · Am J Gastroenterol
354
50A comparison of endoscopic ultrasound, magnetic resonance imaging, and exam under anesthesia for evaluation of Crohn's perianal fistulas.
Schwartz DA · 2001 · Gastroenterology
352
51Differentiating ulcerative colitis from Crohn disease in children and young adults: report of a working group of the North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition and the Crohn's and Colitis Foundation of America.
Bousvaros · 2007 · J Pediatr Gastroenterol Nutr
351
52Defining Disease Severity in Inflammatory Bowel Diseases: Current and Future Directions.
Peyrin-Biroulet L · 2016 · Clin Gastroenterol Hepatol
346
53Clinical features and natural history of Crohn's disease.
Mekhjian HS · 1979 · Gastroenterology
345
54AGA Clinical Practice Guidelines on the Medical Management of Moderate to Severe Luminal and Perianal Fistulizing Crohn's Disease.
Feuerstein JD · 2021 · Gastroenterology
338
55Optimizing anti-TNF treatment in inflammatory bowel disease.
Rutgeerts P · 2004 · Gastroenterology
327
56Healing of perineal Crohn's disease with metronidazole.
Bernstein LH · 1980 · Gastroenterology
326
57Chronic ulcerative colitis and colorectal cancer
Rogler · 2014 · Cancer Lett
321
58Pouchitis following ileal pouch-anal anastomosis: definition, pathogenesis, and treatment
Sandborn · 1994 · Gastroenterology
319
59Changes in clinical characteristics, course, and prognosis of inflammatory bowel disease during the last 5 decades: a population-based study from Copenhagen, Denmark.
Jess · 2007 · Inflamm Bowel Dis
316
60Rising prevalence of venous thromboembolism and its impact on mortality among hospitalized inflammatory bowel disease patients.
Nguyen GC · 2008 · Am J Gastroenterol
312
61A global consensus on the classification, diagnosis and multidisciplinary treatment of perianal fistulising Crohn's disease.
Gecse KB · 2014 · Gut
305
62Magnetic resonance imaging of the effects of infliximab on perianal fistulizing Crohn's disease.
Van Assche G · 2003 · Am J Gastroenterol
300
63Results at up to 20 years after ileal pouch-anal anastomosis for chronic ulcerative colitis
Hahnloser · 2007 · Br J Surg
297
64ECCO-ESCP Consensus on Surgery for Crohn's Disease
Bemelman · 2018 · J Crohns Colitis
290
65European evidence based consensus on the diagnosis and management of Crohn's disease: special situations.
2006 · Gut
288
66Assessing response and loss of response to biological therapies in IBD.
Yanai H · 2011 · Am J Gastroenterol
283
67Review article: the natural history of postoperative Crohn's disease recurrence.
Buisson A · 2012 · Aliment Pharmacol Ther
283
68Laparoscopic ileocaecal resection versus infliximab for terminal ileitis in Crohn's disease: a randomised controlled, open-label, multicentre trial.
Ponsioen CY · 2017 · Lancet Gastroenterol Hepatol
276
69Hidradenitis suppurativa.
Revuz J · 2009 · J Eur Acad Dermatol Venereol
276
70Consensus Recommendations for Evaluation, Interpretation, and Utilization of Computed Tomography and Magnetic Resonance Enterography in Patients With Small Bowel Crohn's Disease.
2018 · Radiology
276
71Risk factors for surgery and recurrence in 907 patients with primary ileocaecal Crohn's disease.
Bernell O · 2000 · Br J Surg
273
72The Real-World Effectiveness and Safety of Vedolizumab for Moderate-Severe Crohn's Disease: Results From the US VICTORY Consortium.
Dulai PS · 2016 · Am J Gastroenterol
270
73Expanded allogeneic adipose-derived stem cells (eASCs) for the treatment of complex perianal fistula in Crohn's disease: results from a multicenter phase I/IIa clinical trial.
de la Portilla F · 2013 · Int J Colorectal Dis
268
74Usual therapy improves perianal Crohn's disease as measured by a new disease activity index. McMaster IBD Study Group.
Irvine EJ · 1995 · J Clin Gastroenterol
267
75Thalidomide therapy for patients with refractory Crohn's disease: an open-label trial.
Ehrenpreis ED · 1999 · Gastroenterology
266
76Allogeneic Bone Marrow-Derived Mesenchymal Stromal Cells Promote Healing of Refractory Perianal Fistulas in Patients With Crohn's Disease.
Molendijk I · 2015 · Gastroenterology
260
77ECCO Guidelines on Inflammatory Bowel Disease and Malignancies.
2023 · J Crohns Colitis
258
78Higher infliximab trough levels are associated with perianal fistula healing in patients with Crohn's disease.
Yarur AJ · 2017 · Aliment Pharmacol Ther
252
79Recent developments in "nonspecific" inflammatory bowel disease (first of two parts).
Kirsner · 1982 · N Engl J Med
251
80Long-term treatment of rectovaginal fistulas in Crohn's disease: response to infliximab in the ACCENT II Study.
Sands BE · 2004 · Clin Gastroenterol Hepatol
250
81Functional gastrointestinal disorders and mood disorders in patients with inactive inflammatory bowel disease: prevalence and impact on health.
Farrokhyar F · 2006 · Inflamm Bowel Dis
248
82Long-term failure after restorative proctocolectomy for ulcerative colitis
Tulchinsky · 2003 · Ann Surg
243
83Ulcerative colitis as a progressive disease: the forgotten evidence.
Torres J · 2012 · Inflamm Bowel Dis
241
84Predictors of severe Crohn's disease.
Loly C · 2008 · Scand J Gastroenterol
241
85Infliximab for Crohn's disease in clinical practice at the Mayo Clinic: the first 100 patients.
Ricart E · 2001 · Am J Gastroenterol
236
86Tacrolimus for the treatment of fistulas in patients with Crohn's disease: a randomized, placebo-controlled trial.
Sandborn WJ · 2003 · Gastroenterology
235
87Favorable effect of 6-mercaptopurine on fistulae of Crohn's disease.
Korelitz BI · 1985 · Dig Dis Sci
232
88Autologous stem cell transplantation for treatment of rectovaginal fistula in perianal Crohn's disease: a new cell-based therapy.
García-Olmo D · 2003 · Int J Colorectal Dis
230
89Genetic factors conferring an increased susceptibility to develop Crohn's disease also influence disease phenotype: results from the IBDchip European Project.
Cleynen I · 2013 · Gut
230
90Early administration of azathioprine vs conventional management of Crohn's Disease: a randomized controlled trial.
Cosnes J · 2013 · Gastroenterology
228
91Embryonic stem cell marker expression pattern in human mesenchymal stem cells derived from bone marrow, adipose tissue, heart and dermis.
Riekstina U · 2009 · Stem Cell Rev Rep
225
92Inflammatory bowel disease characteristics among African Americans, Hispanics, and non-Hispanic Whites: characterization of a large North American cohort.
Nguyen GC · 2006 · Am J Gastroenterol
224
93Changes in the bacterial flora of the neoterminal ileum after ileocolonic resection for Crohn's disease.
Neut · 2002 · Am J Gastroenterol
220
94Outcomes of primary repair of anorectal and rectovaginal fistulas using the endorectal advancement flap.
Sonoda · 2002 · Dis Colon Rectum
219
95Bone marrow and umbilical cord blood human mesenchymal stem cells: state of the art.
Malgieri A · 2010 · Int J Clin Exp Med
218
96Perianal fistulizing Crohn's disease: pathogenesis, diagnosis and therapy.
Panés J · 2017 · Nat Rev Gastroenterol Hepatol
218
97Endorectal advancement flap: are there predictors of failure?
Mizrahi · 2002 · Dis Colon Rectum
217
98Autologous adipose tissue-derived stem cells treatment demonstrated favorable and sustainable therapeutic effect for Crohn's fistula.
Lee WY · 2013 · Stem Cells
216
99Deep Remission at 1 Year Prevents Progression of Early Crohn's Disease.
Ungaro RC · 2020 · Gastroenterology
216
100Treatment of perianal fistulizing Crohn's disease with infliximab alone or as an adjunct to exam under anesthesia with seton placement.
Regueiro M · 2003 · Inflamm Bowel Dis
215